Wilms Tumor Ppt New ⭐ Must See

Wilms Tumor — Informative Paper

Slide 11: Comparison with Other Pediatric Renal Tumors

| Feature | Wilms Tumor | Mesoblastic Nephroma | Rhabdoid Tumor | Clear Cell Sarcoma | |---------|-------------|----------------------|----------------|--------------------| | Age | 1–5 yrs | <3 months | <2 yrs | 1–4 yrs | | Prognosis | Excellent | Excellent | Poor (brain mets) | Intermediate | | Histology | Triphasic | Spindle cells | Eosinophilic inclusions | Clear cells | | Association | WT1, Beckwith-Wiedemann | None | INI1 mutation | YWHAE fusion |

Slide 12: Key Takeaways (Summary)

1. Wilms tumor is the most common pediatric renal cancer (peak 1–5 years).
2. Presents as an asymptomatic abdominal mass → do not palpate aggressively.
3. Diagnosis via abdominal CT; biopsy not routine.
4. Staging (COG) + histology (favorable vs. anaplastic) guides therapy.
5. Treatment: Nephrectomy + chemo ± radiation → >90% cure rate.
6. Genetic syndromes (WAGR, Denys-Drash, Beckwith-Wiedemann) increase risk.
7. Long-term survivors require monitoring for cardiac, renal, and secondary cancer risks.

Causes and Risk Factors

The exact cause of Wilms tumor is not known, but several risk factors have been identified. These include: wilms tumor ppt new

• Genetic predisposition: Wilms tumor can occur in children with a family history of the disease.
• Genetic syndromes: Children with certain genetic syndromes, such as WAGR syndrome (Wilms tumor, Aniridia, Genitourinary anomalies, and mental Retardation), Beckwith-Wiedemann syndrome, and Denys-Drash syndrome, are at increased risk of developing Wilms tumor.
• Birth defects: Children born with certain birth defects, such as hemihypertrophy (uneven growth of the body) and genitourinary anomalies, are also at increased risk.